CDH1-CDKL3 Fusion FISH Probe
The CDH1-CDKL3 Fusion FISH Probe is used to confirm a fusion of the CDH1 and CDKL3 genes. The fusion of the CDH1 and CDKL3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDH1-CDKL3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-RERE | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-REOR | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-REGO | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-REGR | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-REAQ | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-ORRE | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-OROR | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-ORGO | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-GORE | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-GOOR | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-GOGO | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-GOGR | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-GRRE | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-GROR | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-GRGO | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-GRGR | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-AQRE | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-AQOR | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-AQGO | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-AQGR | 20 (40 μL) | 200 μL |
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| CDH1-CDKL3-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH1 Gene Summary
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 1
Chromosome: CHR16: 68771194 -68869444
Locus: 16q22.1
CDKL3 Gene Summary
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Cyclin Dependent Kinase Like 3
Chromosome: CHR5: 133634114 -133702765
Locus: 5q31.1
Gene Diseases
The CDH1 CDKL3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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