CDH1-CA1 Fusion FISH Probe
The CDH1-CA1 Fusion FISH Probe is used to confirm a fusion of the CDH1 and CA1 genes. The fusion of the CDH1 and CA1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDH1-CA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-RERE | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-REOR | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-REGO | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-REGR | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-REAQ | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-ORRE | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-OROR | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-ORGO | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-GORE | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-GOOR | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-GOGO | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-GOGR | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-GRRE | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-GROR | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-GRGO | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-GRGR | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-AQRE | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-AQOR | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-AQGO | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-AQGR | 20 (40 μL) | 200 μL |
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| CDH1-CA1-20-AQAQ | 20 (40 μL) | 200 μL |
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CA1 Gene Summary
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Name: Carbonic Anhydrase 1
Chromosome: CHR8: 86240457 -86290342
Locus: 8q21.2
CDH1 Gene Summary
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 1
Chromosome: CHR16: 68771194 -68869444
Locus: 16q22.1
Gene Diseases
The CDH1 CA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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