CDC42EP5-CYTH1 Fusion FISH Probe
The CDC42EP5-CYTH1 Fusion FISH Probe is used to confirm a fusion of the CDC42EP5 and CYTH1 genes. The fusion of the CDC42EP5 and CYTH1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDC42EP5-CYTH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-RERE | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-REOR | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-REGO | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-REGR | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-REAQ | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-ORRE | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-OROR | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-ORGO | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-GORE | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-GOOR | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-GOGO | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-GOGR | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-GRRE | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-GROR | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-GRGO | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-GRGR | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-AQRE | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-AQOR | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-AQGO | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-AQGR | 20 (40 μL) | 200 μL |
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| CDC42EP5-CYTH1-20-AQAQ | 20 (40 μL) | 200 μL |
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CYTH1 Gene Summary
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Cytohesin 1
Chromosome: CHR17: 76670129 -76778376
Locus: 17q25.3
CDC42EP5 Gene Summary
Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013]
Gene Name: CDC42 Effector Protein 5
Chromosome: CHR19: 54976209 -54984422
Locus: 19q13.42
Gene Diseases
The CDC42EP5 CYTH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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