CDC42EP2-MRPL49 Fusion FISH Probe
The CDC42EP2-MRPL49 Fusion FISH Probe is used to confirm a fusion of the CDC42EP2 and MRPL49 genes. The fusion of the CDC42EP2 and MRPL49 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDC42EP2-MRPL49-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-RERE | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-REOR | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-REGO | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-REGR | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-REAQ | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-ORRE | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-OROR | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-ORGO | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-GORE | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-GOOR | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-GOGO | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-GOGR | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-GRRE | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-GROR | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-GRGO | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-GRGR | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-AQRE | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-AQOR | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-AQGO | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-AQGR | 20 (40 μL) | 200 μL |
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| CDC42EP2-MRPL49-20-AQAQ | 20 (40 μL) | 200 μL |
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MRPL49 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]
Gene Name: Mitochondrial Ribosomal Protein L49
Chromosome: CHR11: 64889654 -64894841
Locus: 11q13.1
CDC42EP2 Gene Summary
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]
Gene Name: CDC42 Effector Protein 2
Chromosome: CHR11: 65082288 -65089900
Locus: 11q13.1
Gene Diseases
The CDC42EP2 MRPL49 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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