CDC42BPB-RGS6 Fusion FISH Probe
The CDC42BPB-RGS6 Fusion FISH Probe is used to confirm a fusion of the CDC42BPB and RGS6 genes. The fusion of the CDC42BPB and RGS6 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDC42BPB-RGS6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-RERE | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-REOR | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-REGO | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-REGR | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-REAQ | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-ORRE | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-OROR | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-ORGO | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-GORE | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-GOOR | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-GOGO | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-GOGR | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-GRRE | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-GROR | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-GRGO | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-GRGR | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-AQRE | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-AQOR | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-AQGO | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-AQGR | 20 (40 μL) | 200 μL |
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| CDC42BPB-RGS6-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC42BPB Gene Summary
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]
Gene Name: CDC42 Binding Protein Kinase Beta
Chromosome: CHR14: 103398715 -103523742
Locus: 14q32.32
RGS6 Gene Summary
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
Gene Name: Regulator Of G Protein Signaling 6
Chromosome: CHR14: 72398816 -73033238
Locus: 14q24.2
Gene Diseases
The CDC42BPB RGS6 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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