CDC42BPA-PRKG1 Fusion FISH Probe
The CDC42BPA-PRKG1 Fusion FISH Probe is used to confirm a fusion of the CDC42BPA and PRKG1 genes. The fusion of the CDC42BPA and PRKG1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDC42BPA-PRKG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-RERE | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-REOR | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-REGO | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-REGR | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-REAQ | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-ORRE | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-OROR | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-ORGO | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-GORE | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-GOOR | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-GOGO | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-GOGR | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-GRRE | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-GROR | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-GRGO | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-GRGR | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-AQRE | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-AQOR | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-AQGO | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-AQGR | 20 (40 μL) | 200 μL |
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| CDC42BPA-PRKG1-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKG1 Gene Summary
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
Gene Name: Protein Kinase, CGMP-dependent, Type I
Chromosome: CHR10: 52750910 -54058110
Locus: 10q11.23-q21.1
CDC42BPA Gene Summary
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]
Gene Name: CDC42 Binding Protein Kinase Alpha
Chromosome: CHR1: 227177565 -227505826
Locus: 1q42.13
Gene Diseases
The CDC42BPA PRKG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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