CDC42BPA-C5 Fusion FISH Probe
The CDC42BPA-C5 Fusion FISH Probe is used to confirm a fusion of the CDC42BPA and C5 genes. The fusion of the CDC42BPA and C5 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CDC42BPA-C5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CDC42BPA-C5-20-AQAQ | 20 (40 μL) | 200 μL |
|
C5 Gene Summary
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Gene Name: Complement C5
Chromosome: CHR9: 123714613 -123812554
Locus: 9q33.2
CDC42BPA Gene Summary
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]
Gene Name: CDC42 Binding Protein Kinase Alpha
Chromosome: CHR1: 227177565 -227505826
Locus: 1q42.13
Gene Diseases
The CDC42BPA C5 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|