CDC27-SYT13 Fusion FISH Probe
The CDC27-SYT13 Fusion FISH Probe is used to confirm a fusion of the CDC27 and SYT13 genes. The fusion of the CDC27 and SYT13 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDC27-SYT13-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-RERE | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-REOR | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-REGO | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-REGR | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-REAQ | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-ORRE | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-OROR | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-ORGO | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-GORE | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-GOOR | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-GOGO | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-GOGR | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-GRRE | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-GROR | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-GRGO | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-GRGR | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-AQRE | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-AQOR | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-AQGO | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-AQGR | 20 (40 μL) | 200 μL |
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| CDC27-SYT13-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC27 Gene Summary
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]
Gene Name: Cell Division Cycle 27
Chromosome: CHR17: 45195310 -45266665
Locus: 17q21.32
SYT13 Gene Summary
This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Synaptotagmin 13
Chromosome: CHR11: 45261852 -45307884
Locus: 11p11.2
Gene Diseases
The CDC27 SYT13 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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