CDC27-SNF8 Fusion FISH Probe
The CDC27-SNF8 Fusion FISH Probe is used to confirm a fusion of the CDC27 and SNF8 genes. The fusion of the CDC27 and SNF8 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDC27-SNF8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-RERE | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-REOR | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-REGO | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-REGR | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-REAQ | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-ORRE | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-OROR | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-ORGO | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-GORE | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-GOOR | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-GOGO | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-GOGR | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-GRRE | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-GROR | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-GRGO | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-GRGR | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-AQRE | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-AQOR | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-AQGO | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-AQGR | 20 (40 μL) | 200 μL |
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| CDC27-SNF8-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC27 Gene Summary
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]
Gene Name: Cell Division Cycle 27
Chromosome: CHR17: 45195310 -45266665
Locus: 17q21.32
SNF8 Gene Summary
The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Name: SNF8, ESCRT-II Complex Subunit
Chromosome: CHR17: 47007458 -47022154
Locus: 17q21.32
Gene Diseases
The CDC27 SNF8 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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