CDC27-MYL4 Fusion FISH Probe
The CDC27-MYL4 Fusion FISH Probe is used to confirm a fusion of the CDC27 and MYL4 genes. The fusion of the CDC27 and MYL4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDC27-MYL4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-RERE | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-REOR | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-REGO | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-REGR | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-REAQ | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-ORRE | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-OROR | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-ORGO | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-GORE | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-GOOR | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-GOGO | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-GOGR | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-GRRE | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-GROR | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-GRGO | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-GRGR | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-AQRE | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-AQOR | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-AQGO | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-AQGR | 20 (40 μL) | 200 μL |
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| CDC27-MYL4-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC27 Gene Summary
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]
Gene Name: Cell Division Cycle 27
Chromosome: CHR17: 45195310 -45266665
Locus: 17q21.32
MYL4 Gene Summary
Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Myosin Light Chain 4
Chromosome: CHR17: 45286427 -45301045
Locus: 17q21.32
Gene Diseases
The CDC27 MYL4 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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