CDC27-BRAF Fusion FISH Probe
The CDC27-BRAF Fusion FISH Probe is used to confirm a fusion of the CDC27 and BRAF genes. The fusion of the CDC27 and BRAF genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CDC27-BRAF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CDC27-BRAF-20-AQAQ | 20 (40 μL) | 200 μL |
|
BRAF Gene Summary
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Gene Name: B-Raf Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR7: 140433812 -140624564
Locus: 7q34
CDC27 Gene Summary
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]
Gene Name: Cell Division Cycle 27
Chromosome: CHR17: 45195310 -45266665
Locus: 17q21.32
Gene Diseases
The CDC27 BRAF Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|