CDC23-CDC25C Fusion FISH Probe
The CDC23-CDC25C Fusion FISH Probe is used to confirm a fusion of the CDC23 and CDC25C genes. The fusion of the CDC23 and CDC25C genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDC23-CDC25C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-RERE | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-REOR | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-REGO | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-REGR | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-REAQ | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-ORRE | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-OROR | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-ORGO | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-GORE | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-GOOR | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-GOGO | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-GOGR | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-GRRE | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-GROR | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-GRGO | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-GRGR | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-AQRE | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-AQOR | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-AQGO | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-AQGR | 20 (40 μL) | 200 μL |
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| CDC23-CDC25C-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC25C Gene Summary
This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]
Gene Name: Cell Division Cycle 25C
Chromosome: CHR5: 137620958 -137667516
Locus: 5q31.2
CDC23 Gene Summary
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
Gene Name: Cell Division Cycle 23
Chromosome: CHR5: 137523336 -137549032
Locus: 5q31.2
Gene Diseases
The CDC23 CDC25C Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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