CD81-NDUFV1 Fusion FISH Probe
The CD81-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the CD81 and NDUFV1 genes. The fusion of the CD81 and NDUFV1 genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD81-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| CD81-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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CD81 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: CD81 Molecule
Chromosome: CHR11: 2398546 -2418649
Locus: 11p15.5
NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
Gene Diseases
The CD81 NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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