CD81-DNM1L Fusion FISH Probe
The CD81-DNM1L Fusion FISH Probe is used to confirm a fusion of the CD81 and DNM1L genes. The fusion of the CD81 and DNM1L genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD81-DNM1L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-RERE | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-REOR | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-REGO | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-REGR | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-REAQ | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-ORRE | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-OROR | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-ORGO | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-ORAQ | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-GORE | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-GOOR | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-GOGO | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-GOGR | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-GOAQ | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-GRRE | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-GROR | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-GRGO | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-GRGR | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-GRAQ | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-AQRE | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-AQOR | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-AQGO | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-AQGR | 20 (40 μL) | 200 μL |
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| CD81-DNM1L-20-AQAQ | 20 (40 μL) | 200 μL |
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CD81 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: CD81 Molecule
Chromosome: CHR11: 2398546 -2418649
Locus: 11p15.5
DNM1L Gene Summary
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Gene Name: Dynamin 1 Like
Chromosome: CHR12: 32832136 -32898584
Locus: 12p11.21
Gene Diseases
The CD81 DNM1L Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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