CD74-UTRN Fusion FISH Probe
The CD74-UTRN Fusion FISH Probe is used to confirm a fusion of the CD74 and UTRN genes. The fusion of the CD74 and UTRN genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD74-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| CD74-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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CD74 Gene Summary
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: CD74 Molecule
Chromosome: CHR5: 149781199 -149792499
Locus: 5q33.1
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The CD74 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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