CD74-SUPT16H Fusion FISH Probe
The CD74-SUPT16H Fusion FISH Probe is used to confirm a fusion of the CD74 and SUPT16H genes. The fusion of the CD74 and SUPT16H genes has been associated with Thyroid Carcinoma, and Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD74-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| CD74-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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CD74 Gene Summary
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: CD74 Molecule
Chromosome: CHR5: 149781199 -149792499
Locus: 5q33.1
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The CD74 SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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