CD74-NDUFV1 Fusion FISH Probe
The CD74-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the CD74 and NDUFV1 genes. The fusion of the CD74 and NDUFV1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD74-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| CD74-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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CD74 Gene Summary
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: CD74 Molecule
Chromosome: CHR5: 149781199 -149792499
Locus: 5q33.1
NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
Gene Diseases
The CD74 NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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