CD59-FBXO3 Fusion FISH Probe
The CD59-FBXO3 Fusion FISH Probe is used to confirm a fusion of the CD59 and FBXO3 genes. The fusion of the CD59 and FBXO3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD59-FBXO3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-RERE | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-REOR | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-REGO | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-REGR | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-REAQ | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-ORRE | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-OROR | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-ORGO | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-GORE | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-GOOR | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-GOGO | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-GOGR | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-GRRE | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-GROR | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-GRGO | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-GRGR | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-AQRE | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-AQOR | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-AQGO | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-AQGR | 20 (40 μL) | 200 μL |
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| CD59-FBXO3-20-AQAQ | 20 (40 μL) | 200 μL |
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CD59 Gene Summary
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: CD59 Molecule (CD59 Blood Group)
Chromosome: CHR11: 33724555 -33758025
Locus: 11p13
FBXO3 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]
Gene Name: F-box Protein 3
Chromosome: CHR11: 33762489 -33796071
Locus: 11p13
Gene Diseases
The CD59 FBXO3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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