CD46-MAPKAPK2 Fusion FISH Probe
The CD46-MAPKAPK2 Fusion FISH Probe is used to confirm a fusion of the CD46 and MAPKAPK2 genes. The fusion of the CD46 and MAPKAPK2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CD46-MAPKAPK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CD46-MAPKAPK2-20-AQAQ | 20 (40 μL) | 200 μL |
|
CD46 Gene Summary
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Gene Name: CD46 Molecule
Chromosome: CHR1: 207925382 -207968861
Locus: 1q32.2
MAPKAPK2 Gene Summary
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase-activated Protein Kinase 2
Chromosome: CHR1: 206858364 -206907630
Locus: 1q32.1
Gene Diseases
The CD46 MAPKAPK2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|