CD2AP-NFKBIE Fusion FISH Probe
The CD2AP-NFKBIE Fusion FISH Probe is used to confirm a fusion of the CD2AP and NFKBIE genes. The fusion of the CD2AP and NFKBIE genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD2AP-NFKBIE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-RERE | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-REOR | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-REGO | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-REGR | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-REAQ | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-ORRE | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-OROR | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-ORGO | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-ORAQ | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-GORE | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-GOOR | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-GOGO | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-GOGR | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-GOAQ | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-GRRE | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-GROR | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-GRGO | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-GRGR | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-GRAQ | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-AQRE | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-AQOR | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-AQGO | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-AQGR | 20 (40 μL) | 200 μL |
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| CD2AP-NFKBIE-20-AQAQ | 20 (40 μL) | 200 μL |
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NFKBIE Gene Summary
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
Gene Name: NFKB Inhibitor Epsilon
Chromosome: CHR6: 44225902 -44233525
Locus: 6p21.1
CD2AP Gene Summary
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]
Gene Name: CD2 Associated Protein
Chromosome: CHR6: 47445524 -47594996
Locus: 6p12.3
Gene Diseases
The CD2AP NFKBIE Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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