CCT4-BIRC6 Fusion FISH Probe
The CCT4-BIRC6 Fusion FISH Probe is used to confirm a fusion of the CCT4 and BIRC6 genes. The fusion of the CCT4 and BIRC6 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCT4-BIRC6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-RERE | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-REOR | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-REGO | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-REGR | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-REAQ | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-ORRE | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-OROR | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-ORGO | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-GORE | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-GOOR | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-GOGO | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-GOGR | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-GRRE | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-GROR | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-GRGO | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-GRGR | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-AQRE | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-AQOR | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-AQGO | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-AQGR | 20 (40 μL) | 200 μL |
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| CCT4-BIRC6-20-AQAQ | 20 (40 μL) | 200 μL |
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CCT4 Gene Summary
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]
Gene Name: Chaperonin Containing TCP1 Subunit 4
Chromosome: CHR2: 62095261 -62115791
Locus: 2p15
BIRC6 Gene Summary
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Gene Name: Baculoviral IAP Repeat Containing 6
Chromosome: CHR2: 32582095 -32843965
Locus: 2p22.3
Gene Diseases
The CCT4 BIRC6 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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