CCT3-STAT6 Fusion FISH Probe
The CCT3-STAT6 Fusion FISH Probe is used to confirm a fusion of the CCT3 and STAT6 genes. The fusion of the CCT3 and STAT6 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCT3-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| CCT3-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
CCT3 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
Gene Name: Chaperonin Containing TCP1 Subunit 3
Chromosome: CHR1: 156278751 -156308206
Locus: 1q22
Gene Diseases
The CCT3 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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