CCT3-SQSTM1 Fusion FISH Probe
The CCT3-SQSTM1 Fusion FISH Probe is used to confirm a fusion of the CCT3 and SQSTM1 genes. The fusion of the CCT3 and SQSTM1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCT3-SQSTM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-RERE | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-REOR | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-REGO | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-REGR | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-REAQ | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-ORRE | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-OROR | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-ORGO | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-GORE | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-GOOR | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-GOGO | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-GOGR | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-GRRE | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-GROR | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-GRGO | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-GRGR | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-AQRE | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-AQOR | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-AQGO | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-AQGR | 20 (40 μL) | 200 μL |
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| CCT3-SQSTM1-20-AQAQ | 20 (40 μL) | 200 μL |
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CCT3 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
Gene Name: Chaperonin Containing TCP1 Subunit 3
Chromosome: CHR1: 156278751 -156308206
Locus: 1q22
SQSTM1 Gene Summary
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
Gene Name: Sequestosome 1
Chromosome: CHR5: 179233387 -179265077
Locus: 5q35.3
Gene Diseases
The CCT3 SQSTM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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