CCT3-NDUFV1 Fusion FISH Probe
The CCT3-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the CCT3 and NDUFV1 genes. The fusion of the CCT3 and NDUFV1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCT3-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| CCT3-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
CCT3 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
Gene Name: Chaperonin Containing TCP1 Subunit 3
Chromosome: CHR1: 156278751 -156308206
Locus: 1q22
Gene Diseases
The CCT3 NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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