CCT3-FAR1 Fusion FISH Probe
The CCT3-FAR1 Fusion FISH Probe is used to confirm a fusion of the CCT3 and FAR1 genes. The fusion of the CCT3 and FAR1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCT3-FAR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-RERE | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-REOR | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-REGO | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-REGR | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-REAQ | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-ORRE | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-OROR | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-ORGO | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-GORE | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-GOOR | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-GOGO | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-GOGR | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-GRRE | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-GROR | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-GRGO | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-GRGR | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-AQRE | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-AQOR | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-AQGO | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-AQGR | 20 (40 μL) | 200 μL |
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| CCT3-FAR1-20-AQAQ | 20 (40 μL) | 200 μL |
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CCT3 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
Gene Name: Chaperonin Containing TCP1 Subunit 3
Chromosome: CHR1: 156278751 -156308206
Locus: 1q22
FAR1 Gene Summary
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Gene Name: Fatty Acyl-CoA Reductase 1
Chromosome: CHR11: 13690205 -13753893
Locus: 11p15.3
Gene Diseases
The CCT3 FAR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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