CCT3-ARHGEF11 Fusion FISH Probe
The CCT3-ARHGEF11 Fusion FISH Probe is used to confirm a fusion of the CCT3 and ARHGEF11 genes. The fusion of the CCT3 and ARHGEF11 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCT3-ARHGEF11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-RERE | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-REOR | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-REGO | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-REGR | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-REAQ | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-ORRE | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-OROR | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-ORGO | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-GORE | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-GOOR | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-GOGO | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-GOGR | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-GRRE | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-GROR | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-GRGO | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-GRGR | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-AQRE | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-AQOR | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-AQGO | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-AQGR | 20 (40 μL) | 200 μL |
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| CCT3-ARHGEF11-20-AQAQ | 20 (40 μL) | 200 μL |
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CCT3 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
Gene Name: Chaperonin Containing TCP1 Subunit 3
Chromosome: CHR1: 156278751 -156308206
Locus: 1q22
ARHGEF11 Gene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Rho Guanine Nucleotide Exchange Factor 11
Chromosome: CHR1: 156904631 -157015162
Locus: 1q23.1
Gene Diseases
The CCT3 ARHGEF11 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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