CCT2-KRT78 Fusion FISH Probe
The CCT2-KRT78 Fusion FISH Probe is used to confirm a fusion of the CCT2 and KRT78 genes. The fusion of the CCT2 and KRT78 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCT2-KRT78-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-RERE | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-REOR | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-REGO | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-REGR | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-REAQ | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-ORRE | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-OROR | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-ORGO | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-GORE | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-GOOR | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-GOGO | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-GOGR | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-GRRE | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-GROR | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-GRGO | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-GRGR | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-AQRE | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-AQOR | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-AQGO | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-AQGR | 20 (40 μL) | 200 μL |
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| CCT2-KRT78-20-AQAQ | 20 (40 μL) | 200 μL |
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CCT2 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Name: Chaperonin Containing TCP1 Subunit 2
Chromosome: CHR12: 69979207 -69995357
Locus: 12q15
KRT78 Gene Summary
This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 78
Chromosome: CHR12: 53232745 -53242778
Locus: 12q13.13
Gene Diseases
The CCT2 KRT78 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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