CCNT2-ACMSD Fusion FISH Probe
The CCNT2-ACMSD Fusion FISH Probe is used to confirm a fusion of the CCNT2 and ACMSD genes. The fusion of the CCNT2 and ACMSD genes has been associated with Liver Hepatocellular Carcinoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCNT2-ACMSD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-RERE | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-REOR | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-REGO | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-REGR | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-REAQ | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-ORRE | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-OROR | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-ORGO | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-GORE | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-GOOR | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-GOGO | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-GOGR | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-GRRE | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-GROR | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-GRGO | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-GRGR | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-AQRE | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-AQOR | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-AQGO | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-AQGR | 20 (40 μL) | 200 μL |
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| CCNT2-ACMSD-20-AQAQ | 20 (40 μL) | 200 μL |
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CCNT2 Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Gene Name: Cyclin T2
Chromosome: CHR2: 135676391 -135716915
Locus: 2q21.3
ACMSD Gene Summary
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
Gene Name: Aminocarboxymuconate Semialdehyde Decarboxylase
Chromosome: CHR2: 135596185 -135659602
Locus: 2q21.3
Gene Diseases
The CCNT2 ACMSD Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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