CCNT1-ADCY6 Fusion FISH Probe
The CCNT1-ADCY6 Fusion FISH Probe is used to confirm a fusion of the CCNT1 and ADCY6 genes. The fusion of the CCNT1 and ADCY6 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCNT1-ADCY6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-RERE | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-REOR | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-REGO | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-REGR | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-REAQ | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-ORRE | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-OROR | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-ORGO | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-GORE | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-GOOR | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-GOGO | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-GOGR | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-GRRE | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-GROR | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-GRGO | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-GRGR | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-AQRE | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-AQOR | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-AQGO | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-AQGR | 20 (40 μL) | 200 μL |
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| CCNT1-ADCY6-20-AQAQ | 20 (40 μL) | 200 μL |
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ADCY6 Gene Summary
This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015]
Gene Name: Adenylate Cyclase 6
Chromosome: CHR12: 49159980 -49182820
Locus: 12q13.12
CCNT1 Gene Summary
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Gene Name: Cyclin T1
Chromosome: CHR12: 49086751 -49110781
Locus: 12q13.11-q13.12
Gene Diseases
The CCNT1 ADCY6 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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