CCNL2-MRPL20 Fusion FISH Probe
The CCNL2-MRPL20 Fusion FISH Probe is used to confirm a fusion of the CCNL2 and MRPL20 genes. The fusion of the CCNL2 and MRPL20 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CCNL2-MRPL20-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CCNL2-MRPL20-20-AQAQ | 20 (40 μL) | 200 μL |
|
MRPL20 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Gene Name: Mitochondrial Ribosomal Protein L20
Chromosome: CHR1: 1337275 -1342693
Locus: 1p36.33
CCNL2 Gene Summary
The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Cyclin L2
Chromosome: CHR1: 1321090 -1334718
Locus: 1p36.33
Gene Diseases
The CCNL2 MRPL20 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|