CCNI-MRPL1 Fusion FISH Probe
The CCNI-MRPL1 Fusion FISH Probe is used to confirm a fusion of the CCNI and MRPL1 genes. The fusion of the CCNI and MRPL1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCNI-MRPL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-RERE | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-REOR | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-REGO | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-REGR | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-REAQ | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-ORRE | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-OROR | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-ORGO | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-GORE | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-GOOR | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-GOGO | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-GOGR | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-GRRE | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-GROR | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-GRGO | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-GRGR | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-AQRE | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-AQOR | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-AQGO | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-AQGR | 20 (40 μL) | 200 μL |
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| CCNI-MRPL1-20-AQAQ | 20 (40 μL) | 200 μL |
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CCNI Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]
Gene Name: Cyclin I
Chromosome: CHR4: 77969176 -77997125
Locus: 4q21.1
MRPL1 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein L1
Chromosome: CHR4: 78783804 -78873944
Locus: 4q21.1
Gene Diseases
The CCNI MRPL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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