CCND3-VPS52 Fusion FISH Probe
The CCND3-VPS52 Fusion FISH Probe is used to confirm a fusion of the CCND3 and VPS52 genes. The fusion of the CCND3 and VPS52 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCND3-VPS52-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-RERE | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-REOR | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-REGO | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-REGR | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-REAQ | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-ORRE | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-OROR | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-ORGO | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-GORE | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-GOOR | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-GOGO | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-GOGR | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-GRRE | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-GROR | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-GRGO | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-GRGR | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-AQRE | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-AQOR | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-AQGO | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-AQGR | 20 (40 μL) | 200 μL |
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| CCND3-VPS52-20-AQAQ | 20 (40 μL) | 200 μL |
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CCND3 Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Name: Cyclin D3
Chromosome: CHR6: 41902670 -42016610
Locus: 6p21.1
VPS52 Gene Summary
This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: VPS52, GARP Complex Subunit
Chromosome: CHR6_qbl_hap6: 4450267 -4471898
Locus: 6p21.32
Gene Diseases
The CCND3 VPS52 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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