CCNB2-RNF111 Fusion FISH Probe
The CCNB2-RNF111 Fusion FISH Probe is used to confirm a fusion of the CCNB2 and RNF111 genes. The fusion of the CCNB2 and RNF111 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCNB2-RNF111-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-RERE | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-REOR | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-REGO | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-REGR | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-REAQ | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-ORRE | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-OROR | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-ORGO | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-GORE | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-GOOR | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-GOGO | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-GOGR | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-GRRE | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-GROR | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-GRGO | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-GRGR | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-AQRE | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-AQOR | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-AQGO | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-AQGR | 20 (40 μL) | 200 μL |
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| CCNB2-RNF111-20-AQAQ | 20 (40 μL) | 200 μL |
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CCNB2 Gene Summary
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
Gene Name: Cyclin B2
Chromosome: CHR15: 59397283 -59417244
Locus: 15q22.2
RNF111 Gene Summary
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Gene Name: Ring Finger Protein 111
Chromosome: CHR15: 59279864 -59389253
Locus: 15q22.1-q22.2
Gene Diseases
The CCNB2 RNF111 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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