CCM2-C7ORF10 Fusion FISH Probe
The CCM2-C7ORF10 Fusion FISH Probe is used to confirm a fusion of the CCM2 and C7ORF10 genes. The fusion of the CCM2 and C7ORF10 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCM2-C7ORF10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-RERE | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-REOR | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-REGO | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-REGR | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-REAQ | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-ORRE | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-OROR | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-ORGO | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-GORE | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-GOOR | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-GOGO | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-GOGR | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-GRRE | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-GROR | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-GRGO | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-GRGR | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-AQRE | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-AQOR | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-AQGO | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-AQGR | 20 (40 μL) | 200 μL |
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| CCM2-C7ORF10-20-AQAQ | 20 (40 μL) | 200 μL |
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CCM2 Gene Summary
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Gene Name: CCM2 Scaffolding Protein
Chromosome: CHR7: 45039344 -45116069
Locus: 7p13
Gene Diseases
The CCM2 C7ORF10 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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