CCDC6-UBE2D1 Fusion FISH Probe
The CCDC6-UBE2D1 Fusion FISH Probe is used to confirm a fusion of the CCDC6 and UBE2D1 genes. The fusion of the CCDC6 and UBE2D1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCDC6-UBE2D1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-RERE | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-REOR | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-REGO | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-REGR | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-REAQ | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-ORRE | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-OROR | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-ORGO | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-GORE | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-GOOR | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-GOGO | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-GOGR | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-GRRE | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-GROR | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-GRGO | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-GRGR | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-AQRE | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-AQOR | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-AQGO | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-AQGR | 20 (40 μL) | 200 μL |
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| CCDC6-UBE2D1-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE2D1 Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Name: Ubiquitin Conjugating Enzyme E2 D1
Chromosome: CHR10: 60094738 -60130513
Locus: 10q21.1
CCDC6 Gene Summary
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]
Gene Name: Coiled-coil Domain Containing 6
Chromosome: CHR10: 61548505 -61666414
Locus: 10q21.2
Gene Diseases
The CCDC6 UBE2D1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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