CCDC6-ANK3 Fusion FISH Probe
The CCDC6-ANK3 Fusion FISH Probe is used to confirm a fusion of the CCDC6 and ANK3 genes. The fusion of the CCDC6 and ANK3 genes has been associated with Ovarian Serous Cystadenocarcinoma, Ovarian Serous Cystadenocarcinoma, Ovarian Serous Cystadenocarcinoma, Ovarian Serous Cystadenocarcinoma, Lung Adenocarcinoma, Uterine Corpus Endometrial Carcinoma, Uterine Corpus Endometrial Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCDC6-ANK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-RERE | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-REOR | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-REGO | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-REGR | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-REAQ | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-ORRE | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-OROR | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-ORGO | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-GORE | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-GOOR | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-GOGO | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-GOGR | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-GRRE | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-GROR | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-GRGO | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-GRGR | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-AQRE | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-AQOR | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-AQGO | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-AQGR | 20 (40 μL) | 200 μL |
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| CCDC6-ANK3-20-AQAQ | 20 (40 μL) | 200 μL |
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ANK3 Gene Summary
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Ankyrin 3
Chromosome: CHR10: 61786055 -62493284
Locus: 10q21.2
CCDC6 Gene Summary
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]
Gene Name: Coiled-coil Domain Containing 6
Chromosome: CHR10: 61548505 -61666414
Locus: 10q21.2
Gene Diseases
The CCDC6 ANK3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Ovarian Serous Cystadenocarcinoma |
| Ovarian Serous Cystadenocarcinoma |
| Ovarian Serous Cystadenocarcinoma |
| Ovarian Serous Cystadenocarcinoma |
| Lung Adenocarcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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