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CCDC47-TERT Fusion FISH Probe

The CCDC47-TERT Fusion FISH Probe is used to confirm a fusion of the CCDC47 and TERT genes. The fusion of the CCDC47 and TERT genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
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SKU Test Kits Buffer Dye Color Order Now
CCDC47-TERT-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CCDC47-TERT-20-RERE 20 (40 μL) 200 μL
CCDC47-TERT-20-REOR 20 (40 μL) 200 μL
CCDC47-TERT-20-REGO 20 (40 μL) 200 μL
CCDC47-TERT-20-REGR 20 (40 μL) 200 μL
CCDC47-TERT-20-REAQ 20 (40 μL) 200 μL
CCDC47-TERT-20-ORRE 20 (40 μL) 200 μL
CCDC47-TERT-20-OROR 20 (40 μL) 200 μL
CCDC47-TERT-20-ORGO 20 (40 μL) 200 μL
CCDC47-TERT-20-ORAQ 20 (40 μL) 200 μL
CCDC47-TERT-20-GORE 20 (40 μL) 200 μL
CCDC47-TERT-20-GOOR 20 (40 μL) 200 μL
CCDC47-TERT-20-GOGO 20 (40 μL) 200 μL
CCDC47-TERT-20-GOGR 20 (40 μL) 200 μL
CCDC47-TERT-20-GOAQ 20 (40 μL) 200 μL
CCDC47-TERT-20-GRRE 20 (40 μL) 200 μL
CCDC47-TERT-20-GROR 20 (40 μL) 200 μL
CCDC47-TERT-20-GRGO 20 (40 μL) 200 μL
CCDC47-TERT-20-GRGR 20 (40 μL) 200 μL
CCDC47-TERT-20-GRAQ 20 (40 μL) 200 μL
CCDC47-TERT-20-AQRE 20 (40 μL) 200 μL
CCDC47-TERT-20-AQOR 20 (40 μL) 200 μL
CCDC47-TERT-20-AQGO 20 (40 μL) 200 μL
CCDC47-TERT-20-AQGR 20 (40 μL) 200 μL
CCDC47-TERT-20-AQAQ 20 (40 μL) 200 μL

TERT Gene Summary

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

Gene Name: Telomerase Reverse Transcriptase

Chromosome: CHR5: 1253286 -1295162

Locus: 5p15.33

CCDC47 Gene Summary

The Coiled-coil Domain Containing 47 (CCDC47) gene is located on chr17 :61822609-61851088 at 17q23.3.

Gene Name: Coiled-coil Domain Containing 47

Chromosome: CHR17: 61822609 -61851088

Locus: 17q23.3

Gene Diseases

The CCDC47 TERT Fusion has been associated with the following diseases:

Disease Name
Adrenocortical Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
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Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
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Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines.

The TERT gene, which encodes a telomerase subunit, has long interested cancer researchers because it's required for cell proliferation and immortalization in 80-90% of human cancers. This study analyzed TERT expression across 10 human cancer lines using our TERT FISH probe. TERT expression was highly heterogeneous across different cancers, with variations in cellular location of the TERT protein, number of transcription sites, and ratio of transcription sites to gene copies.
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Analysis of mucosal melanoma whole-genome landscapes reveals clinically relevant genomic aberrations

Unlike cutaneous melanoma, the genomics of mucosal melanoma (MM) remain poorly understood, which has hindered the development of targeted therapy for MM patients. In order to account for this gap in data, this team performed whole-genome sequencing on 65 MM samples to identify genomic alterations with prognostic and/or therapeutic implications. Our CDK4 and TERT probes were used to detect amplification of the genes.
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