CCDC40-PRKG1 Fusion FISH Probe
The CCDC40-PRKG1 Fusion FISH Probe is used to confirm a fusion of the CCDC40 and PRKG1 genes. The fusion of the CCDC40 and PRKG1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCDC40-PRKG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-RERE | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-REOR | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-REGO | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-REGR | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-REAQ | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-ORRE | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-OROR | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-ORGO | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-GORE | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-GOOR | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-GOGO | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-GOGR | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-GRRE | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-GROR | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-GRGO | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-GRGR | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-AQRE | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-AQOR | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-AQGO | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-AQGR | 20 (40 μL) | 200 μL |
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| CCDC40-PRKG1-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKG1 Gene Summary
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
Gene Name: Protein Kinase, CGMP-dependent, Type I
Chromosome: CHR10: 52750910 -54058110
Locus: 10q11.23-q21.1
CCDC40 Gene Summary
This gene encodes a protein that is necessary for motile cilia function. It functions in correct left-right axis formation by regulating the assembly of the inner dynein arm and the dynein regulatory complexes, which control ciliary beat. Mutations in this gene cause ciliary dyskinesia type 15, a disorder due to defects in cilia motility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Coiled-coil Domain Containing 40
Chromosome: CHR17: 78010430 -78074412
Locus: 17q25.3
Gene Diseases
The CCDC40 PRKG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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