SEARCH OUR PRODUCT CATALOG

FISH Probe Products & Services
Request More Information

CCDC127-TERT Fusion FISH Probe

The CCDC127-TERT Fusion FISH Probe is used to confirm a fusion of the CCDC127 and TERT genes. The fusion of the CCDC127 and TERT genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
CCDC127-TERT-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CCDC127-TERT-20-RERE 20 (40 μL) 200 μL
CCDC127-TERT-20-REOR 20 (40 μL) 200 μL
CCDC127-TERT-20-REGO 20 (40 μL) 200 μL
CCDC127-TERT-20-REGR 20 (40 μL) 200 μL
CCDC127-TERT-20-REAQ 20 (40 μL) 200 μL
CCDC127-TERT-20-ORRE 20 (40 μL) 200 μL
CCDC127-TERT-20-OROR 20 (40 μL) 200 μL
CCDC127-TERT-20-ORGO 20 (40 μL) 200 μL
CCDC127-TERT-20-ORAQ 20 (40 μL) 200 μL
CCDC127-TERT-20-GORE 20 (40 μL) 200 μL
CCDC127-TERT-20-GOOR 20 (40 μL) 200 μL
CCDC127-TERT-20-GOGO 20 (40 μL) 200 μL
CCDC127-TERT-20-GOGR 20 (40 μL) 200 μL
CCDC127-TERT-20-GOAQ 20 (40 μL) 200 μL
CCDC127-TERT-20-GRRE 20 (40 μL) 200 μL
CCDC127-TERT-20-GROR 20 (40 μL) 200 μL
CCDC127-TERT-20-GRGO 20 (40 μL) 200 μL
CCDC127-TERT-20-GRGR 20 (40 μL) 200 μL
CCDC127-TERT-20-GRAQ 20 (40 μL) 200 μL
CCDC127-TERT-20-AQRE 20 (40 μL) 200 μL
CCDC127-TERT-20-AQOR 20 (40 μL) 200 μL
CCDC127-TERT-20-AQGO 20 (40 μL) 200 μL
CCDC127-TERT-20-AQGR 20 (40 μL) 200 μL
CCDC127-TERT-20-AQAQ 20 (40 μL) 200 μL

TERT Gene Summary

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

Gene Name: Telomerase Reverse Transcriptase

Chromosome: CHR5: 1253286 -1295162

Locus: 5p15.33

CCDC127 Gene Summary

The Coiled-coil Domain Containing 127 (CCDC127) gene is located on chr5 :204874-218297 at 5p15.33.

Gene Name: Coiled-coil Domain Containing 127

Chromosome: CHR5: 204874 -218297

Locus: 5p15.33

Gene Diseases

The CCDC127 TERT Fusion has been associated with the following diseases:

Disease Name
Glioblastoma Multiforme

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
Read More

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
Read More

Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines.

The TERT gene, which encodes a telomerase subunit, has long interested cancer researchers because it's required for cell proliferation and immortalization in 80-90% of human cancers. This study analyzed TERT expression across 10 human cancer lines using our TERT FISH probe. TERT expression was highly heterogeneous across different cancers, with variations in cellular location of the TERT protein, number of transcription sites, and ratio of transcription sites to gene copies.
Read More

Analysis of mucosal melanoma whole-genome landscapes reveals clinically relevant genomic aberrations

Unlike cutaneous melanoma, the genomics of mucosal melanoma (MM) remain poorly understood, which has hindered the development of targeted therapy for MM patients. In order to account for this gap in data, this team performed whole-genome sequencing on 65 MM samples to identify genomic alterations with prognostic and/or therapeutic implications. Our CDK4 and TERT probes were used to detect amplification of the genes.
Read More