CBX5-NFE2 Fusion FISH Probe
The CBX5-NFE2 Fusion FISH Probe is used to confirm a fusion of the CBX5 and NFE2 genes. The fusion of the CBX5 and NFE2 genes has been associated with Kidney Renal Clear Cell Carcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CBX5-NFE2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-RERE | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-REOR | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-REGO | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-REGR | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-REAQ | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-ORRE | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-OROR | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-ORGO | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-GORE | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-GOOR | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-GOGO | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-GOGR | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-GRRE | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-GROR | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-GRGO | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-GRGR | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-AQRE | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-AQOR | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-AQGO | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-AQGR | 20 (40 μL) | 200 μL |
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| CBX5-NFE2-20-AQAQ | 20 (40 μL) | 200 μL |
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NFE2 Gene Summary
The Nuclear Factor, Erythroid 2 (NFE2) gene is located on chr12 :54685895-54694791 at 12q13.13.
Gene Name: Nuclear Factor, Erythroid 2
Chromosome: CHR12: 54685895 -54694791
Locus: 12q13.13
CBX5 Gene Summary
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Chromobox 5
Chromosome: CHR12: 54624730 -54673915
Locus: 12q13.13
Gene Diseases
The CBX5 NFE2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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