CBX3-CDK14 Fusion FISH Probe
The CBX3-CDK14 Fusion FISH Probe is used to confirm a fusion of the CBX3 and CDK14 genes. The fusion of the CBX3 and CDK14 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CBX3-CDK14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-RERE | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-REOR | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-REGO | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-REGR | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-REAQ | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-ORRE | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-OROR | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-ORGO | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-ORAQ | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-GORE | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-GOOR | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-GOGO | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-GOGR | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-GOAQ | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-GRRE | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-GROR | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-GRGO | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-GRGR | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-GRAQ | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-AQRE | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-AQOR | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-AQGO | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-AQGR | 20 (40 μL) | 200 μL |
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| CBX3-CDK14-20-AQAQ | 20 (40 μL) | 200 μL |
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CDK14 Gene Summary
PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
Gene Name: Cyclin Dependent Kinase 14
Chromosome: CHR7: 90338711 -90839904
Locus: 7q21.13
CBX3 Gene Summary
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Gene Name: Chromobox 3
Chromosome: CHR7: 26240830 -26253227
Locus: 7p15.2
Gene Diseases
The CBX3 CDK14 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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