CBLC-PVR Fusion FISH Probe
The CBLC-PVR Fusion FISH Probe is used to confirm a fusion of the CBLC and PVR genes. The fusion of the CBLC and PVR genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CBLC-PVR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-RERE | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-REOR | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-REGO | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-REGR | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-REAQ | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-ORRE | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-OROR | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-ORGO | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-ORAQ | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-GORE | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-GOOR | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-GOGO | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-GOGR | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-GOAQ | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-GRRE | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-GROR | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-GRGO | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-GRGR | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-GRAQ | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-AQRE | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-AQOR | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-AQGO | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-AQGR | 20 (40 μL) | 200 μL |
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| CBLC-PVR-20-AQAQ | 20 (40 μL) | 200 μL |
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PVR Gene Summary
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Name: Poliovirus Receptor
Chromosome: CHR19: 45147097 -45169428
Locus: 19q13.31
CBLC Gene Summary
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Cbl Proto-oncogene C
Chromosome: CHR19: 45281125 -45303903
Locus: 19q13.32
Gene Diseases
The CBLC PVR Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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