CBLB-IL17RE Fusion FISH Probe
The CBLB-IL17RE Fusion FISH Probe is used to confirm a fusion of the CBLB and IL17RE genes. The fusion of the CBLB and IL17RE genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CBLB-IL17RE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-RERE | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-REOR | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-REGO | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-REGR | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-REAQ | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-ORRE | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-OROR | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-ORGO | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-ORAQ | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-GORE | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-GOOR | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-GOGO | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-GOGR | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-GOAQ | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-GRRE | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-GROR | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-GRGO | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-GRGR | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-GRAQ | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-AQRE | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-AQOR | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-AQGO | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-AQGR | 20 (40 μL) | 200 μL |
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| CBLB-IL17RE-20-AQAQ | 20 (40 μL) | 200 μL |
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CBLB Gene Summary
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
Gene Name: Cbl Proto-oncogene B
Chromosome: CHR3: 105377108 -105587887
Locus: 3q13.11
IL17RE Gene Summary
This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Gene Name: Interleukin 17 Receptor E
Chromosome: CHR3: 9944295 -9958084
Locus: 3p25.3
Gene Diseases
The CBLB IL17RE Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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