CBL-CXCR5 Fusion FISH Probe
The CBL-CXCR5 Fusion FISH Probe is used to confirm a fusion of the CBL and CXCR5 genes. The fusion of the CBL and CXCR5 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CBL-CXCR5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-RERE | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-REOR | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-REGO | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-REGR | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-REAQ | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-ORRE | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-OROR | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-ORGO | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-ORAQ | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-GORE | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-GOOR | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-GOGO | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-GOGR | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-GOAQ | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-GRRE | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-GROR | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-GRGO | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-GRGR | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-GRAQ | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-AQRE | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-AQOR | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-AQGO | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-AQGR | 20 (40 μL) | 200 μL |
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| CBL-CXCR5-20-AQAQ | 20 (40 μL) | 200 μL |
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CXCR5 Gene Summary
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: C-X-C Motif Chemokine Receptor 5
Chromosome: CHR11: 118754474 -118766980
Locus: 11q23.3
CBL Gene Summary
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
Gene Name: Cbl Proto-oncogene
Chromosome: CHR11: 119076989 -119178859
Locus: 11q23.3
Gene Diseases
The CBL CXCR5 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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