CBFB-CA7 Fusion FISH Probe
The CBFB-CA7 Fusion FISH Probe is used to confirm a fusion of the CBFB and CA7 genes. The fusion of the CBFB and CA7 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CBFB-CA7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-RERE | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-REOR | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-REGO | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-REGR | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-REAQ | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-ORRE | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-OROR | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-ORGO | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-ORAQ | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-GORE | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-GOOR | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-GOGO | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-GOGR | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-GOAQ | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-GRRE | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-GROR | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-GRGO | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-GRGR | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-GRAQ | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-AQRE | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-AQOR | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-AQGO | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-AQGR | 20 (40 μL) | 200 μL |
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| CBFB-CA7-20-AQAQ | 20 (40 μL) | 200 μL |
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CA7 Gene Summary
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Carbonic Anhydrase 7
Chromosome: CHR16: 66878281 -66888049
Locus: 16q22.1
CBFB Gene Summary
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Core-binding Factor Beta Subunit
Chromosome: CHR16: 67063049 -67134958
Locus: 16q22.1
Gene Diseases
The CBFB CA7 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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