CBFB-ATP13A3 Fusion FISH Probe
The CBFB-ATP13A3 Fusion FISH Probe is used to confirm a fusion of the CBFB and ATP13A3 genes. The fusion of the CBFB and ATP13A3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CBFB-ATP13A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-RERE | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-REOR | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-REGO | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-REGR | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-REAQ | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-ORRE | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-OROR | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-ORGO | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-GORE | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-GOOR | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-GOGO | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-GOGR | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-GRRE | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-GROR | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-GRGO | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-GRGR | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-AQRE | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-AQOR | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-AQGO | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-AQGR | 20 (40 μL) | 200 μL |
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| CBFB-ATP13A3-20-AQAQ | 20 (40 μL) | 200 μL |
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CBFB Gene Summary
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Core-binding Factor Beta Subunit
Chromosome: CHR16: 67063049 -67134958
Locus: 16q22.1
ATP13A3 Gene Summary
ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011).[supplied by OMIM, Aug 2008]
Gene Name: ATPase 13A3
Chromosome: CHR3: 194123402 -194188968
Locus: 3q29
Gene Diseases
The CBFB ATP13A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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