CBFA2T2-SNTA1 Fusion FISH Probe
The CBFA2T2-SNTA1 Fusion FISH Probe is used to confirm a fusion of the CBFA2T2 and SNTA1 genes. The fusion of the CBFA2T2 and SNTA1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CBFA2T2-SNTA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CBFA2T2-SNTA1-20-AQAQ | 20 (40 μL) | 200 μL |
|
SNTA1 Gene Summary
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]
Gene Name: Syntrophin Alpha 1
Chromosome: CHR20: 31995762 -32031698
Locus: 20q11.21
CBFA2T2 Gene Summary
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Gene Name: CBFA2/RUNX1 Translocation Partner 2
Chromosome: CHR20: 32077927 -32237837
Locus: 20q11.21-q11.22
Gene Diseases
The CBFA2T2 SNTA1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|