CBFA2T2-REM1 Fusion FISH Probe
The CBFA2T2-REM1 Fusion FISH Probe is used to confirm a fusion of the CBFA2T2 and REM1 genes. The fusion of the CBFA2T2 and REM1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CBFA2T2-REM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-RERE | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-REOR | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-REGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-REGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-REAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-ORRE | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-OROR | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-ORGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-GORE | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-GOOR | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-GOGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-GOGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-GRRE | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-GROR | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-GRGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-GRGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-AQRE | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-AQOR | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-AQGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-AQGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-REM1-20-AQAQ | 20 (40 μL) | 200 μL |
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CBFA2T2 Gene Summary
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Gene Name: CBFA2/RUNX1 Translocation Partner 2
Chromosome: CHR20: 32077927 -32237837
Locus: 20q11.21-q11.22
REM1 Gene Summary
The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]
Gene Name: RRAD And GEM Like GTPase 1
Chromosome: CHR20: 30063104 -30072708
Locus: 20q11.21
Gene Diseases
The CBFA2T2 REM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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