CBFA2T2-DOK5 Fusion FISH Probe
The CBFA2T2-DOK5 Fusion FISH Probe is used to confirm a fusion of the CBFA2T2 and DOK5 genes. The fusion of the CBFA2T2 and DOK5 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CBFA2T2-DOK5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-RERE | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-REOR | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-REGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-REGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-REAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-ORRE | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-OROR | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-ORGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-ORAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-GORE | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-GOOR | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-GOGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-GOGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-GOAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-GRRE | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-GROR | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-GRGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-GRGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-GRAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-AQRE | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-AQOR | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-AQGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-AQGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-DOK5-20-AQAQ | 20 (40 μL) | 200 μL |
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CBFA2T2 Gene Summary
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Gene Name: CBFA2/RUNX1 Translocation Partner 2
Chromosome: CHR20: 32077927 -32237837
Locus: 20q11.21-q11.22
DOK5 Gene Summary
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Name: Docking Protein 5
Chromosome: CHR20: 53092265 -53267710
Locus: 20q13.2
Gene Diseases
The CBFA2T2 DOK5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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