CBFA2T2-BCL2L1 Fusion FISH Probe
The CBFA2T2-BCL2L1 Fusion FISH Probe is used to confirm a fusion of the CBFA2T2 and BCL2L1 genes. The fusion of the CBFA2T2 and BCL2L1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CBFA2T2-BCL2L1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-RERE | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-REOR | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-REGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-REGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-REAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-ORRE | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-OROR | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-ORGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-GORE | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-GOOR | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-GOGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-GOGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-GRRE | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-GROR | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-GRGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-GRGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-AQRE | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-AQOR | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-AQGO | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-AQGR | 20 (40 μL) | 200 μL |
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| CBFA2T2-BCL2L1-20-AQAQ | 20 (40 μL) | 200 μL |
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BCL2L1 Gene Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
Gene Name: BCL2 Like 1
Chromosome: CHR20: 30252260 -30310656
Locus: 20q11.21
CBFA2T2 Gene Summary
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Gene Name: CBFA2/RUNX1 Translocation Partner 2
Chromosome: CHR20: 32077927 -32237837
Locus: 20q11.21-q11.22
Gene Diseases
The CBFA2T2 BCL2L1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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